# IFNA2

Source: https://onco.cc/targets/ifna2/  
OnCo record `ifna2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

IFNA2 (Interferon alpha-2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Produced by macrophages, IFN-alpha have antiviral activities.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.96, clinical 0.81).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: interferon alpha 2; Interferon alpha-2; IFN-alphaA
- Tags: cancer-genes-wave
- Symbol: IFNA2
- Class: other
- Biology: Produced by macrophages, IFN-alpha have antiviral activities. Location: Secreted (UniProt). Locus 9p21.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.81. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5423: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5423
- UniProt P01563: https://www.uniprot.org/uniprotkb/P01563/entry
- NCBI Gene 3440: https://www.ncbi.nlm.nih.gov/gene/3440
- Ensembl ENSG00000188379: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000188379

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ifna2.json