# IGF2

Source: https://onco.cc/targets/igf2/  
OnCo record `igf2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

IGF2 (Insulin-like growth factor 2) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer, Ovarian cancer and Pancreatic ductal adenocarcinoma.

## Summary

The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development.

CIViC holds 5 clinical evidence items and 0 assertions across 1 variant, naming Linsitinib, Cabazitaxel, Ganitumab and Docetaxel and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: insulin like growth factor 2; Insulin-like growth factor 2; FLJ44734; IGF-II; C11orf43
- Tags: cancer-genes-wave
- Symbol: IGF2
- Class: other
- Biology: The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Location: Secreted (UniProt). Locus 11p15.5 (HGNC).
- Where found: Prostate cancer: CIViC evidence names this disease; Ovarian cancer: CIViC evidence names this disease; Pancreatic ductal adenocarcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 5 therapies; CIViC holds 5 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5466: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5466
- UniProt P01344: https://www.uniprot.org/uniprotkb/P01344/entry
- NCBI Gene 3481: https://www.ncbi.nlm.nih.gov/gene/3481
- Ensembl ENSG00000167244: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167244

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/igf2.json