# IGF2R

Source: https://onco.cc/targets/igf2r/  
OnCo record `igf2r` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

IGF2R (Cation-independent mannose-6-phosphate receptor) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.91, animal model 0.40, genetic association 0.42, somatic mutation 0.72).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: insulin like growth factor 2 receptor; Cation-independent mannose-6-phosphate receptor; CD222; MPR1; CIMPR; M6P-R; CI-M6PR; CI-MPR; MPR300
- Tags: cancer-genes-wave
- Symbol: IGF2R
- Class: other
- Biology: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation by binding DPP4. Location: Golgi apparatus membrane; Endosome membrane (UniProt). Locus 6q25.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:5467: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5467
- UniProt P11717: https://www.uniprot.org/uniprotkb/P11717/entry
- NCBI Gene 3482: https://www.ncbi.nlm.nih.gov/gene/3482
- Ensembl ENSG00000197081: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000197081

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/igf2r.json