# IL2RG

Source: https://onco.cc/targets/il2rg/  
OnCo record `il2rg` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

IL2RG (Cytokine receptor common subunit gamma) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Skin cancer, Renal cell carcinoma, Leukaemia and 3 more.

## Summary

Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.90, animal model 0.54, genetic association 0.00, clinical 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: interleukin 2 receptor subunit gamma; Cytokine receptor common subunit gamma; CD132; SCIDX1; IMD4
- Tags: cancer-genes-wave
- Symbol: IL2RG
- Class: other
- Biology: Common subunit for the receptors for a variety of interleukins. Probably in association with IL15RA, involved in the stimulation of neutrophil phagocytosis by IL15. Location: Cell membrane; Cell surface (UniProt). Locus Xq13.1 (HGNC).
- Where found: Skin cancer: Open Targets association 0.56 with skin cancer (MONDO_0002898); Renal cell carcinoma: Open Targets association 0.54 with renal cell carcinoma (MONDO_0005086); Leukaemia: Open Targets association 0.54 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.51 with non-Hodgkin lymphoma (MONDO_0018908); Melanoma: Open Targets association 0.55 with melanoma (MONDO_0005105); Cutaneous T-cell lymphoma: Open Targets association 0.55 with primary cutaneous T-cell non-Hodgkin lymphoma (MONDO_0000607)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6010: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6010
- UniProt P31785: https://www.uniprot.org/uniprotkb/P31785/entry
- NCBI Gene 3561: https://www.ncbi.nlm.nih.gov/gene/3561
- Ensembl ENSG00000147168: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000147168

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome)](https://onco.cc/cancers/cutaneous-t-cell-lymphoma/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Melanoma](https://onco.cc/cancers/melanoma/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/il2rg.json