# IL7R

Source: https://onco.cc/targets/il7r/  
OnCo record `il7r` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

IL7R (Interleukin-7 receptor subunit alpha) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Skin cancer, Leukaemia, Non-Hodgkin lymphoma and 5 more.

## Summary

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).

CIViC holds 3 clinical evidence items and 0 assertions across 3 variants. Open Targets scores its association with cancer at 0.70 (direct and indirect evidence; datatypes literature 0.98, animal model 0.42, genetic association 0.36, somatic mutation 0.86). IntOGen calls it a driver in 4 cohorts (3 activating, 1 loss-of-function), covering Acute Lymphoblastic Leukaemia, Oesophageal Adenocarcinoma, Hepatocellular Carcinoma, Stomach Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: interleukin 7 receptor; Interleukin-7 receptor subunit alpha; CD127; IL7RA; lnc-IL7R; IL-7Ralpha; IL7Ralpha; sIL-7R; CDw127
- Tags: cancer-genes-wave
- Symbol: IL7R
- Class: oncogene
- Biology: Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). Location: Cell membrane; Secreted (UniProt). Locus 5p13.2 (HGNC).
- Where found: Skin cancer: Open Targets association 0.64 with skin cancer (MONDO_0002898); Leukaemia: Open Targets association 0.62 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.61 with non-Hodgkin lymphoma (MONDO_0018908); Oesophageal cancer: IntOGen driver in 1 cohort (ESCA); Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC); Gastric & gastro-oesophageal junction cancer: IntOGen driver in 1 cohort (STAD)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 3 cohorts; IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: T-cell Acute Lymphoblastic Leukaemia; Childhood B-cell Acute Lymphoblastic Leukaemia; B-lymphoblastic Leukaemia/lymphoma, BCR-ABL1-like.

## Sources

- HGNC HGNC:6024: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6024
- UniProt P16871: https://www.uniprot.org/uniprotkb/P16871/entry
- NCBI Gene 3575: https://www.ncbi.nlm.nih.gov/gene/3575
- Ensembl ENSG00000168685: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000168685

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/il7r.json