# IMPDH1

Source: https://onco.cc/targets/impdh1/  
OnCo record `impdh1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

IMPDH1 (Inosine-5'-monophosphate dehydrogenase 1) is an enzyme. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it. Tied to Leukaemia, Non-Hodgkin lymphoma, Myeloproliferative neoplasms and 2 more.

## Summary

Catalyses the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumours.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.94, animal model 0.50, genetic association 0.00, clinical 0.91).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: inosine monophosphate dehydrogenase 1; Inosine-5'-monophosphate dehydrogenase 1; sWSS2608; LCA11; RP10
- Tags: cancer-genes-wave
- Symbol: IMPDH1
- Class: enzyme
- Biology: Catalyses the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumours. Location: Cytoplasm; Nucleus (UniProt). Locus 7q32.1 (HGNC).
- Where found: Leukaemia: Open Targets association 0.56 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.54 with non-Hodgkin lymphoma (MONDO_0018908); Myeloproliferative neoplasms: Open Targets association 0.53 with myeloproliferative neoplasm (MONDO_0020076); Acute lymphoblastic leukaemia: Open Targets association 0.53 with acute lymphoblastic leukaemia (MONDO_0004967); Acute myeloid leukaemia: Open Targets association 0.53 with acute myeloid leukaemia (MONDO_0018874)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.92. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6052: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6052
- UniProt P20839: https://www.uniprot.org/uniprotkb/P20839/entry
- NCBI Gene 3614: https://www.ncbi.nlm.nih.gov/gene/3614
- Ensembl ENSG00000106348: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000106348

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/impdh1.json