# INCENP

Source: https://onco.cc/targets/incenp/  
OnCo record `incenp` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

INCENP (Inner centromere protein) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Acts as a scaffold regulating CPC localisation and activity.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.50, genetic association 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: inner centromere protein; Inner centromere protein; FLJ31633
- Tags: cancer-genes-wave
- Symbol: INCENP
- Class: other
- Biology: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilisation and spindle assembly. Acts as a scaffold regulating CPC localisation and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin. Activates AURKB and AURKC. Location: Nucleus; Chromosome, centromere; Cytoplasm, cytoskeleton, spindle; Midbody (UniProt). Locus 11q12.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6058: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6058
- UniProt Q9NQS7: https://www.uniprot.org/uniprotkb/Q9NQS7/entry
- NCBI Gene 3619: https://www.ncbi.nlm.nih.gov/gene/3619
- Ensembl ENSG00000149503: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000149503

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/incenp.json