# Indigotindisulfonate sodium (indigo carmine)

Source: https://onco.cc/drugs/indigotindisulfonate/  
OnCo record `indigotindisulfonate` (Imaging agent). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A blue dye given into a vein near the end of an operation on the pelvis, so the surgeon can see blue urine coming from each ureter and check they were not damaged.

## Summary

Provepharm's Bludigo (NDA 216264, first approved 8 July 2022) "is indicated for use as a visualization aid in the cystoscopic assessment of the integrity of the ureters in adults following urological and gynecological open, robotic, or endoscopic surgical procedures".

## Fields

- Kind: Imaging agent
- Status: approved
- Last checked: 2026-11-04
- Also known as: indigotindisulfonate; indigo carmine; Bludigo
- Tags: contrast-agents-gaps-2026-11; diagnostic
- Brand: Bludigo
- Modality: Blue dye contrast agent for imaging the ureters during cystoscopy (intravenous)
- Mechanism: Given into a vein, the dye is excreted by the kidneys and colours the urine blue, so urine jets from each ureteric opening can be seen in the bladder.
- Approvals: US 2022: Visualisation aid in cystoscopic assessment of ureteric integrity after urological and gynaecological surgery

## Sources

- Drugs@FDA Bludigo (NDA 216264): https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=216264
- DailyMed label: Bludigo: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2b91c39d-5f15-4dcf-9d3d-b378470e6bd7

## Connected records

- technologies: [Fluorescence-guided surgery](https://onco.cc/technologies/fluorescence-guided-surgery/), [Ureteric stents and nephrostomy tubes for malignant ureteric obstruction (Memokath 051)](https://onco.cc/technologies/ureteric-stents-and-nephrostomy/)

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