# ING1

Source: https://onco.cc/targets/ing1/  
OnCo record `ing1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ING1 (Inhibitor of growth protein 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma, Colorectal cancer and Endometrial cancer.

## Summary

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumour suppressor gene.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.49, somatic mutation 0.73, genetic literature 0.61). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Colorectal Adenocarcinoma, Endometrial Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: inhibitor of growth family member 1; Inhibitor of growth protein 1; p33ING1; p33ING1b; p24ING1c; p33; p47; p47ING1a
- Tags: cancer-genes-wave
- Symbol: ING1
- Class: tumor-suppressor
- Biology: Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumour suppressor gene. Location: Nucleus (UniProt). Locus 13q34 (HGNC).
- Where found: Head and neck squamous cell carcinoma: Open Targets association 0.59 with head and neck squamous cell carcinoma (MONDO_0010150); Colorectal cancer: IntOGen driver in 1 cohort (COADREAD); Endometrial cancer: IntOGen driver in 1 cohort (UCEC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6062: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6062
- UniProt Q9UK53: https://www.uniprot.org/uniprotkb/Q9UK53/entry
- NCBI Gene 3621: https://www.ncbi.nlm.nih.gov/gene/3621
- Ensembl ENSG00000153487: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153487

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/)

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JSON: https://onco.cc/api/v1/entities/ing1.json