# INRG staging and risk groups

Source: https://onco.cc/terms/inrg-staging/  
OnCo record `inrg-staging` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

INRG staging is the international system that sorts neuroblastoma into four risk groups, from the lowest (often observed, sometimes regressing on its own) to high risk (about half of patients), using age under 18 months, spread, MYCN amplification, 11q status, ploidy and histology.

## Summary

International Neuroblastoma Risk Group (2009): stages L1/L2 (localised, by image-defined risk factors), M (metastatic), MS (infant metastatic to skin/liver/marrow). Risk groups combine stage, age (<18 months), MYCN amplification, 11q aberration, ploidy and histology. Roughly 50% of patients are high risk; very-low-risk L1/MS may be observed and regress spontaneously.

## Fields

- Kind: Term
- Last checked: 2026-09-07
- Also known as: INRGSS; INRG stage; INRG risk group; INRG classification; INPC; INPC histology; International Neuroblastoma Pathology Classification; Shimada classification; INSS; International Neuroblastoma Staging System; image-defined risk factors; IDRF; stage L1; stage L2; stage M; stage MS

## Sources

- Wikipedia: https://en.wikipedia.org/wiki/Neuroblastoma#Staging
- Wikipedia: https://en.wikipedia.org/wiki/Neuroblastoma#Staging

## Connected records

- cancers: [High-risk neuroblastoma](https://onco.cc/cancers/neuroblastoma-high-risk/), [Intermediate-risk neuroblastoma](https://onco.cc/cancers/neuroblastoma-intermediate-risk/), [Low-risk neuroblastoma (INRG very low and low risk, including stage MS)](https://onco.cc/cancers/neuroblastoma-low-risk/), [Neuroblastoma (paediatric)](https://onco.cc/cancers/neuroblastoma/)
- people: [Susan L. Cohn](https://onco.cc/people/susan-cohn/)
- bottlenecks: [Rare and paediatric cancers without markets](https://onco.cc/bottlenecks/b-rare-cancers/)
- terms: [MIBG Curie and SIOPEN scores](https://onco.cc/terms/curie-siopen-score/), [Segmental chromosomal aberrations and ploidy (neuroblastoma)](https://onco.cc/terms/segmental-chromosomal-aberrations/), [Urinary catecholamine metabolites (VMA and HVA)](https://onco.cc/terms/urinary-catecholamines/)

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