# INSPIRE (Singlera methylation and fragmentomics case-control study)

Source: https://onco.cc/trials/inspire-singlera/  
OnCo record `inspire-singlera` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A Chinese study of about 5,000 people building a blood test that combines DNA methylation and fragment patterns for 13 cancers.

## Summary

INSPIRE (NCT06440018) is an observational study sponsored by Singlera Genomics Inc with Fudan University, Hubei Cancer Hospital, China-Japan Friendship Hospital and others. It develops and validates in a blinded set a machine-learning multi-cancer early detection model integrating circulating DNA methylation and fragmentomics.

The registry record, read on 29 October 2026, gives its status as unknown (the sponsor last updated it on 21 February 2025), with an estimated 5,350 participants, a start on 20 July 2024 and primary completion expected on 28 February 2025.

## Fields

- Kind: Trial
- Last checked: 2026-10-29
- Also known as: INSPIRE
- Registry id: NCT06440018
- Phase: observational
- Setting: People newly diagnosed with one of 13 cancers and people without cancer at Chinese hospitals, in a case-control development and blinded validation
- Sponsor: Singlera Genomics Inc. with Fudan University, Hubei Cancer Hospital, China-Japan Friendship Hospital, Shanxi Province Cancer Hospital, Xuhui Central Hospital, Fudan University, Shanghai Electric Power Hospital, Shanghai East Hospital of Tongji University, First Affiliated Hospital Xi'an Jiaotong University, GaoZhou People's Hosipital, Anhui Provincial Hospital, Beijing Friendship Hospital
- Enrolled: 5350

## Sources

- ClinicalTrials.gov NCT06440018: https://clinicaltrials.gov/study/NCT06440018

## Connected records

- fronts: [Early Detection & Screening](https://onco.cc/fronts/early-detection/)
- technologies: [cfDNA fragmentomics](https://onco.cc/technologies/fragmentomics/), [Liquid biopsy (ctDNA)](https://onco.cc/technologies/liquid-biopsy/), [Multi-cancer early detection (MCED)](https://onco.cc/technologies/mced/)
- companies: [Singlera Genomics](https://onco.cc/companies/singlera/)
- drugs: [PanSeer](https://onco.cc/drugs/panseer/)

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