# IRX4

Source: https://onco.cc/targets/irx4/  
OnCo record `irx4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

IRX4 (Iroquois-class homeodomain protein IRX-4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Likely to be an important mediator of ventricular differentiation during cardiac development.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.46, genetic association 0.84).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: iroquois homeobox 4; Iroquois-class homeodomain protein IRX-4
- Tags: cancer-genes-wave
- Symbol: IRX4
- Class: other
- Biology: Likely to be an important mediator of ventricular differentiation during cardiac development. Location: Nucleus (UniProt). Locus 5p15.33 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6129: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6129
- UniProt P78413: https://www.uniprot.org/uniprotkb/P78413/entry
- NCBI Gene 50805: https://www.ncbi.nlm.nih.gov/gene/50805
- Ensembl ENSG00000113430: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000113430

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/irx4.json