# Innovative Therapies for Children with Cancer (ITCC)

Source: https://onco.cc/companies/itcc/  
OnCo record `itcc` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Europe's network of children's hospitals that run the first trials of new cancer drugs in children, so that European children can access experimental medicines close to home.

## Summary

Founded in 2003 and coordinated from Gustave Roussy, ITCC links more than 60 European paediatric oncology centres and around 25 research laboratories to conduct early-phase (phase 1 and 2) trials of new anticancer agents in children and adolescents. It runs academic platform trials including ESMART (molecularly matched combinations at relapse, the European counterpart of Pediatric MATCH) and the MAPPYACTS sequencing programme, partners with industry on paediatric investigation plans, and works with SIOP Europe and ACCELERATE on regulatory strategy. ITCC-P4 built a library of paediatric patient-derived xenograft models for preclinical testing under the IMI programme.

## Fields

- Kind: Company
- Last checked: 2026-09-10
- Also known as: ITCC; ITCC consortium
- Tags: cooperative-group; nci-coverage; paediatric
- HQ: Villejuif
- Type: cooperative-group
- Website: https://www.itcc-consortium.org

## Notes

- Early-phase paediatric trials network
- ESMART platform trial
- MAPPYACTS molecular profiling
- ITCC-P4 preclinical PDX platform
- Industry partnerships for paediatric investigation plans

## Sources

- ITCC: https://www.itcc-consortium.org

## Connected records

- cancers: [Diffuse midline glioma, H3 K27-altered (including DIPG)](https://onco.cc/cancers/dipg-dmg/), [Neuroblastoma (paediatric)](https://onco.cc/cancers/neuroblastoma/), [Paediatric low-grade glioma](https://onco.cc/cancers/paediatric-low-grade-glioma/), [Rhabdomyosarcoma](https://onco.cc/cancers/rhabdomyosarcoma/)
- technologies: [Comprehensive genomic profiling](https://onco.cc/technologies/cgp/), [Patient-derived xenografts](https://onco.cc/technologies/pdx-models/)
- institutions: [ACCELERATE](https://onco.cc/institutions/accelerate-platform/), [Great Ormond Street Hospital for Children](https://onco.cc/institutions/great-ormond-street/), [Gustave Roussy](https://onco.cc/institutions/gustave-roussy/), [Princess Máxima Center for Pediatric Oncology](https://onco.cc/institutions/princess-maxima/), [SIOP Europe (European Society for Paediatric Oncology)](https://onco.cc/institutions/siop-europe/)
- trials: [NCI-COG Pediatric MATCH (APEC1621)](https://onco.cc/trials/pediatric-match/)
- people: [Gilles Vassal](https://onco.cc/people/gilles-vassal/), [Pamela Kearns](https://onco.cc/people/pamela-kearns/)
- bottlenecks: [Rare and paediatric cancers without markets](https://onco.cc/bottlenecks/b-rare-cancers/), [Trials enrol too few, too slowly](https://onco.cc/bottlenecks/b-trial-enrolment/)
- terms: [RACE for Children Act](https://onco.cc/terms/race-for-children-act/)
- roadmaps: [Paediatric oncology roadmap: cooperative-group cures → engineered immunity → drugs developed for children first](https://onco.cc/roadmaps/paediatric-oncology-roadmap/)

---
JSON: https://onco.cc/api/v1/entities/itcc.json