# ITGA2B

Source: https://onco.cc/targets/itga2b/  
OnCo record `itga2b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ITGA2B (Integrin alpha-IIb) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognises the sequence R-G-D in a wide array of ligands. It recognises the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.81, affected pathway 0.97, animal model 0.55, genetic association 0.07).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: integrin subunit alpha 2b; Integrin alpha-IIb; CD41B; CD41; PPP1R93; GPIIb; GP2B
- Tags: cancer-genes-wave
- Symbol: ITGA2B
- Class: other
- Biology: Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. It recognises the sequence R-G-D in a wide array of ligands. It recognises the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface. Integrin ITGA2B:ITGB3 is also the receptor of erythrocyte-specific ICAM4 ligand involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets. Location: Cell membrane (UniProt). Locus 17q21.31 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6138: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6138
- UniProt P08514: https://www.uniprot.org/uniprotkb/P08514/entry
- NCBI Gene 3674: https://www.ncbi.nlm.nih.gov/gene/3674
- Ensembl ENSG00000005961: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000005961

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/itga2b.json