# ITGA6

Source: https://onco.cc/targets/itga6/  
OnCo record `itga6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ITGA6 (Integrin alpha-6) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: integrin subunit alpha 6; Integrin alpha-6; CD49f; VLA-6; ITGA6A; ITGA6B
- Tags: cancer-genes-wave
- Symbol: ITGA6
- Class: other
- Biology: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion. Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signalling. ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signalling. ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signalling. Location: Cell membrane (UniProt). Locus 2q31.1 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.51 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6142: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6142
- UniProt P23229: https://www.uniprot.org/uniprotkb/P23229/entry
- NCBI Gene 3655: https://www.ncbi.nlm.nih.gov/gene/3655
- Ensembl ENSG00000091409: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000091409

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/itga6.json