# ITPKB

Source: https://onco.cc/targets/itpkb/  
OnCo record `itpkb` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ITPKB (Inositol-trisphosphate 3-kinase B) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: inositol-trisphosphate 3-kinase B; Inositol-trisphosphate 3-kinase B; IP3KB; IP3-3KB
- Tags: cancer-genes-wave
- Symbol: ITPKB
- Class: kinase
- Biology: Catalyses the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. Location: Cytoplasm, cytoskeleton; Cytoplasm; Endoplasmic reticulum (UniProt). Locus 1q42.12 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6179: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6179
- UniProt P27987: https://www.uniprot.org/uniprotkb/P27987/entry
- NCBI Gene 3707: https://www.ncbi.nlm.nih.gov/gene/3707
- Ensembl ENSG00000143772: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143772

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/itpkb.json