# ITR-251

Source: https://onco.cc/drugs/itr-251/  
OnCo record `itr-251` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ITR-251 is an experimental small molecule from Iteria Biopharma, in phase 1 trials for metastatic castration-resistant prostate cancer and advanced solid tumours.

## Summary

ITR-251 is a small molecule from Iteria Biopharma. A potent and selective, reversible inhibitor of monoamine oxidase A (MAO-A) with limited capacity to cross the blood-brain barrier. Its furthest stage is phase 1, for metastatic castration-resistant prostate cancer and advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Phase 1/1b NCT07870096 is registered but NOT YET RECRUITING; first in advanced solid tumours, then with androgen receptor pathway inhibitors and ADT in metastatic castration-resistant prostate cancer. If the writer prefers stage to mean dosed patients, use preclinical. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: ITR-251
- Modality: Small molecule
- Mechanism: A potent and selective, reversible inhibitor of monoamine oxidase A (MAO-A) with limited capacity to cross the blood-brain barrier.

## Sources

- Iteria Biopharma: iteriabiopharma.com: https://iteriabiopharma.com/pipeline/
- Iteria Biopharma: clinicaltrials.gov: https://clinicaltrials.gov/study/NCT07870096
- ClinicalTrials.gov: trials of ITR-251: https://clinicaltrials.gov/search?intr=ITR-251

## Connected records

- cancers: [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/), [Metastatic castration-resistant prostate cancer](https://onco.cc/cancers/prostate-mcrpc/)
- targets: [MAO-A (MAOA)](https://onco.cc/targets/maoa/)
- companies: [Iteria Biopharma](https://onco.cc/companies/iteria-biopharma/)
- trials: [ITR-251 in Patients With Advanced Solid Tumors](https://onco.cc/trials/nct07870096/)

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JSON: https://onco.cc/api/v1/entities/itr-251.json