# IWWM response criteria (Waldenstrom macroglobulinaemia)

Source: https://onco.cc/terms/iwwm-response/  
OnCo record `iwwm-response` (Term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

These consensus criteria judge response in Waldenstrom macroglobulinaemia, mainly by the fall in the abnormal IgM protein in the blood.

## Summary

The consensus panel of the 6th International Workshop on Waldenstrom's Macroglobulinaemia (Owen and colleagues, British Journal of Haematology 2013) updated the response criteria, since categorical responses improved with new regimens and predict outcome. Open problems it names are the different speed of IgM fall with different treatments and a mismatch between IgM and bone marrow response with some regimens; planned sequential marrow assessments are encouraged in trials.

## Fields

- Kind: Term
- Last checked: 2026-11-04
- Also known as: IWWM response criteria; IWWM-6 criteria

## Sources

- Owen et al., Response assessment in Waldenstrom macroglobulinaemia: update from the VIth International Workshop (Br J Haematol 2013): https://doi.org/10.1111/bjh.12102

## Connected records

- terms: [Complete response (CR) and partial response (PR)](https://onco.cc/terms/complete-response-term/), [IMWG response criteria for myeloma (2016, with MRD)](https://onco.cc/terms/imwg-response-criteria/)
- cancers: [Waldenström macroglobulinaemia](https://onco.cc/cancers/waldenstrom/)

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