# JAG1

Source: https://onco.cc/targets/jag1/  
OnCo record `jag1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

JAG1 (jagged canonical Notch ligand 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Ligand for multiple Notch receptors and involved in the mediation of Notch signalling. May be involved in cell-fate decisions during haematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development.

Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.78, animal model 0.59, genetic association 0.54).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: jagged canonical Notch ligand 1; HJ1; CD339; JAGL1
- Tags: cancer-genes-wave
- Symbol: JAG1
- Class: other
- Biology: Ligand for multiple Notch receptors and involved in the mediation of Notch signalling. May be involved in cell-fate decisions during haematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Location: Membrane; Cell membrane (UniProt). Locus 20p12.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6188: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6188
- UniProt P78504: https://www.uniprot.org/uniprotkb/P78504/entry
- NCBI Gene 182: https://www.ncbi.nlm.nih.gov/gene/182
- Ensembl ENSG00000101384: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000101384

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

---
JSON: https://onco.cc/api/v1/entities/jag1.json