# JAG2

Source: https://onco.cc/targets/jag2/  
OnCo record `jag2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

JAG2 (jagged canonical Notch ligand 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Putative Notch ligand involved in the mediation of Notch signalling. Involved in limb development.

Open Targets scores its association with cancer at 0.59 (direct and indirect evidence; datatypes literature 0.94, affected pathway 0.91, animal model 0.53, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: jagged canonical Notch ligand 2
- Tags: cancer-genes-wave
- Symbol: JAG2
- Class: other
- Biology: Putative Notch ligand involved in the mediation of Notch signalling. Involved in limb development. Location: Membrane (UniProt). Locus 14q32.33 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6189: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6189
- UniProt Q9Y219: https://www.uniprot.org/uniprotkb/Q9Y219/entry
- NCBI Gene 3714: https://www.ncbi.nlm.nih.gov/gene/3714
- Ensembl ENSG00000184916: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184916

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

---
JSON: https://onco.cc/api/v1/entities/jag2.json