# JAK3

Source: https://onco.cc/targets/jak3/  
OnCo record `jak3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

JAK3 (Tyrosine-protein kinase JAK3) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a drug target, an oncogene driver and a biomarker, and an approved or late-stage drug is recorded against it. Tied to Myeloproliferative neoplasms, Leukaemia, Non-Hodgkin lymphoma and 5 more.

## Summary

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signalling events in both innate and adaptive immunity and plays a crucial role in haematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R.

CIViC holds 3 clinical evidence items and 0 assertions across 8 variants, naming Atezolizumab and Tofacitinib. Open Targets scores its association with cancer at 0.77 (direct and indirect evidence; datatypes clinical 0.96, affected pathway 0.61, literature 0.95, genetic association 0.18, somatic mutation 0.97, animal model 0.53). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Lymphoblastic Leukaemia.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Janus kinase 3; Tyrosine-protein kinase JAK3; L-JAK; JAK3_HUMAN; JAK-3
- Tags: cancer-genes-wave
- Symbol: JAK3
- Class: kinase
- Biology: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signalling events in both innate and adaptive immunity and plays a crucial role in haematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. Location: Endomembrane system; Cytoplasm (UniProt). Locus 19p13.11 (HGNC).
- Where found: Myeloproliferative neoplasms: Open Targets association 0.73 with myeloproliferative neoplasm (MONDO_0020076); Leukaemia: Open Targets association 0.67 with leukaemia (MONDO_0005059); Non-Hodgkin lymphoma: Open Targets association 0.65 with non-Hodgkin lymphoma (MONDO_0018908); Skin cancer: Open Targets association 0.58 with skin cancer (MONDO_0002898); Lung cancer: Open Targets association 0.55 with lung cancer (MONDO_0008903); Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.96; IntOGen calls it an activating (Act) driver in 1 cohort; CIViC holds 3 clinical evidence items on its variants. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: T-cell Acute Lymphoblastic Leukaemia.

## Sources

- HGNC HGNC:6193: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6193
- UniProt P52333: https://www.uniprot.org/uniprotkb/P52333/entry
- NCBI Gene 3718: https://www.ncbi.nlm.nih.gov/gene/3718
- Ensembl ENSG00000105639: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000105639

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Acute lymphoblastic leukaemia](https://onco.cc/cancers/all-leukemia/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Myeloproliferative neoplasms (PV, ET, myelofibrosis)](https://onco.cc/cancers/myeloproliferative-neoplasms/), [Non-Hodgkin lymphoma (all types)](https://onco.cc/cancers/non-hodgkin-lymphoma/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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