# JAZF1

Source: https://onco.cc/targets/jazf1/  
OnCo record `jazf1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

JAZF1 (Juxtaposed with another zinc finger protein 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Skin cancer and Prostate cancer.

## Summary

Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.92, genetic association 0.68, somatic mutation 0.49).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: JAZF zinc finger 1; Juxtaposed with another zinc finger protein 1; TIP27; DKFZp761K2222; ZNF802
- Tags: cancer-genes-wave
- Symbol: JAZF1
- Class: transcription
- Biology: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity. Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD. Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue. Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity. Location: Nucleus (UniProt). Locus 7p15.2-p15.1 (HGNC).
- Where found: Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Prostate cancer: Open Targets association 0.52 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:28917: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28917
- UniProt Q86VZ6: https://www.uniprot.org/uniprotkb/Q86VZ6/entry
- NCBI Gene 221895: https://www.ncbi.nlm.nih.gov/gene/221895
- Ensembl ENSG00000153814: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153814

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/jazf1.json