# Jeffrey D. Bradley

Source: https://onco.cc/people/jeffrey-bradley/  
OnCo record `jeffrey-bradley` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led RTOG 0617, the trial that showed higher radiation doses do not help in stage III lung cancer and set today's 60 Gy standard.

## Summary

Jeffrey Bradley was principal investigator of RTOG 0617, which unexpectedly found that escalating the dose to 74 Gy worsened survival compared with 60 Gy in stage III NSCLC, a result that fixed the standard dose and refocused the field on precision and cardiac sparing. He led the NRG proton-versus-photon lung trial and chairs thoracic radiotherapy committees in NRG Oncology.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: radiotherapy; lung; nrg-oncology
- Role: Professor and Vice Chair of Radiation Oncology, University of Pennsylvania Perelman School of Medicine
- Specialisms: Thoracic radiation oncology; Dose escalation; Proton therapy; Cooperative-group trials

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Bradley%20JD%5BAuthor%5D%20RTOG%200617

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Proton therapy](https://onco.cc/technologies/proton-therapy/)
- institutions: [Abramson Cancer Center, University of Pennsylvania](https://onco.cc/institutions/penn-abramson/)
- trials: [PACIFIC-2](https://onco.cc/trials/pacific-2/)

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