# Jeffrey S. Dome

Source: https://onco.cc/people/jeffrey-dome/  
OnCo record `jeffrey-dome` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led the COG renal tumour committee that used biology to tailor Wilms tumour treatment.

## Summary

Jeffrey Dome (Children's National Hospital) chaired the Children's Oncology Group renal tumour committee and led the AREN trials that incorporated loss of heterozygosity at 1p and 16q and lung nodule response into risk-adapted Wilms tumour therapy, allowing many children to avoid lung radiotherapy or doxorubicin. His laboratory studies telomerase and relapse biology in Wilms tumour.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: paediatric; wilms-tumor; cooperative-group
- Role: Senior Vice President, Center for Cancer and Blood Disorders, Children's National Hospital, Washington DC
- Specialisms: Wilms tumour; Paediatric renal tumours; Risk-adapted therapy; Cooperative-group trials

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Dome%20JS%5BAuthor%5D%20Wilms

## Connected records

- cancers: [Wilms tumour (nephroblastoma)](https://onco.cc/cancers/wilms-tumor/)
- institutions: [Children's National Hospital](https://onco.cc/institutions/childrens-national-hospital/)
- terms: [De-escalation, escalation and response-adapted therapy](https://onco.cc/terms/de-escalation/), [Radiotherapy](https://onco.cc/terms/radiotherapy/)

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