# K-DETEK (SPOT-MAS in adults without symptoms, Vietnam)

Source: https://onco.cc/trials/k-detek/  
OnCo record `k-detek` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The prospective Vietnamese study of about 9,000 people without symptoms that measured how the SPOT-MAS blood test performs in screening.

## Summary

K-DETEK (NCT05227261) is an observational study sponsored by Gene Solutions with Medical University of Ho Chi Minh City, Hanoi Medical University, Hanoi Oncology Hospital and others. Its primary objective was the performance of the cell-free DNA test in detecting cancer early, with the accuracy of its predicted tissue of origin against imaging as a secondary objective. Results were published in BMC Medicine in 2025: 43 of 9,024 tested positive and 17 had cancer.

The registry record, read on 29 October 2026, gives its status as completed, with 9,057 participants enrolled, a start on 10 April 2022 and primary completion on 10 April 2023.

## Fields

- Kind: Trial
- Status: completed
- Last checked: 2026-10-29
- Also known as: K-DETEK
- Registry id: NCT05227261
- Phase: observational
- Setting: Adults aged 40 or older without symptoms at hospitals across Vietnam, given the SPOT-MAS blood test and followed for 12 months
- Sponsor: Gene Solutions with Medical University of Ho Chi Minh City, Hanoi Medical University, Hanoi Oncology Hospital, Hue Central Hospital, Da Nang Oncology Hospital, Thong Nhat Dong Nai General Hospital, Dong Nai General Hospital, Van Hanh General Hospital, Can Tho Oncology Hospital, Medic Medical Center, Le Van Thinh Hospital, 115 People's Hospital, Xuyen A Hospital, Medical Genetics Institute
- Enrolled: 9057

## Sources

- ClinicalTrials.gov NCT05227261: https://clinicaltrials.gov/study/NCT05227261

## Connected records

- fronts: [Early Detection & Screening](https://onco.cc/fronts/early-detection/)
- technologies: [Liquid biopsy (ctDNA)](https://onco.cc/technologies/liquid-biopsy/), [Multi-cancer early detection (MCED)](https://onco.cc/technologies/mced/)
- drugs: [SPOT-MAS](https://onco.cc/drugs/spot-mas/)
- companies: [Gene Solutions](https://onco.cc/companies/gene-solutions/)
- key papers: [Prospective validation study: a non-invasive circulating tumor DNA-based assay for simultaneous early detection of multiple cancers in asymptomatic adults](https://onco.cc/key-papers/paper-spot-mas-k-detek-bmc-med-2025/)

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