# KAT6A

Source: https://onco.cc/targets/kat6a/  
OnCo record `kat6a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KAT6A (Histone acetyltransferase KAT6A) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Oesophageal cancer, Skin cancer, Breast cancer and 5 more.

## Summary

Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.98, animal model 0.48, genetic association 0.00, somatic mutation 0.86). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Oesophageal Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: lysine acetyltransferase 6A; Histone acetyltransferase KAT6A; ZNF220; RUNXBP2; MYST3
- Tags: cancer-genes-wave
- Symbol: KAT6A
- Class: tumor-suppressor
- Biology: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. May play a role in leukemogenic gene transcription. Location: Nucleus; Nucleus, nucleolus; Nucleus, nucleoplasm; Nucleus, PML body (UniProt). Locus 8p11.21 (HGNC).
- Where found: Oesophageal cancer: IntOGen driver in 1 cohort (ESCA); Skin cancer: Open Targets association 0.57 with skin cancer (MONDO_0002898); Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254); Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575); Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903); Ovarian cancer: Open Targets association 0.52 with ovarian cancer (MONDO_0008170)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:13013: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:13013
- UniProt Q92794: https://www.uniprot.org/uniprotkb/Q92794/entry
- NCBI Gene 7994: https://www.ncbi.nlm.nih.gov/gene/7994
- Ensembl ENSG00000083168: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000083168

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Melanoma](https://onco.cc/cancers/melanoma/), [Oesophageal and junctional adenocarcinoma](https://onco.cc/cancers/oesophageal-adenocarcinoma/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/kat6a.json