# KAT6B

Source: https://onco.cc/targets/kat6b/  
OnCo record `kat6b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KAT6B (Histone acetyltransferase KAT6B) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Nasopharyngeal carcinoma, Prostate cancer and 4 more.

## Summary

Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development.

Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.89, animal model 0.28, genetic association 0.00, somatic mutation 0.87). IntOGen calls it a driver in 5 cohorts (1 activating, 4 loss-of-function), covering Invasive Breast Carcinoma, Low-Grade Glioma, NOS, Medulloblastoma, Nasopharyngeal Carcinoma, Prostate Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: lysine acetyltransferase 6B; Histone acetyltransferase KAT6B; querkopf; qkf; Morf; MOZ2; MYST4
- Tags: cancer-genes-wave
- Symbol: KAT6B
- Class: transcription
- Biology: Histone acetyltransferase which may be involved in both positive and negative regulation of transcription. Required for RUNX2-dependent transcriptional activation. May be involved in cerebral cortex development. Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Location: Nucleus (UniProt). Locus 10q22.2 (HGNC).
- Where found: Breast cancer: Open Targets association 0.58 with breast cancer (MONDO_0007254); IntOGen driver in 1 cohort (BRCA); Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC); Prostate cancer: IntOGen driver in 1 cohort (PRAD); Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575); Medulloblastoma: IntOGen driver in 1 cohort (MBL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 4 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Low-Grade Glioma, NOS.

## Sources

- HGNC HGNC:17582: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17582
- UniProt Q8WYB5: https://www.uniprot.org/uniprotkb/Q8WYB5/entry
- NCBI Gene 23522: https://www.ncbi.nlm.nih.gov/gene/23522
- Ensembl ENSG00000156650: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000156650

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/), [Melanoma](https://onco.cc/cancers/melanoma/), [Nasopharyngeal carcinoma](https://onco.cc/cancers/nasopharyngeal/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/kat6b.json