# KCNA3

Source: https://onco.cc/targets/kcna3/  
OnCo record `kcna3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KCNA3 (Potassium voltage-gated channel subfamily A member 3) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Mediates the voltage-dependent potassium ion permeability of excitable membranes.

Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.94, genetic association 0.47, clinical 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: potassium voltage-gated channel subfamily A member 3; Potassium voltage-gated channel subfamily A member 3; Kv1.3; MK3; HLK3; HPCN3; RP11-284N8.3
- Tags: cancer-genes-wave
- Symbol: KCNA3
- Class: other
- Biology: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Lacks voltage-gated potassium channel activity. Location: Cell membrane; Cytoplasm, perinuclear region (UniProt). Locus 1p13.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6221: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6221
- UniProt P22001: https://www.uniprot.org/uniprotkb/P22001/entry
- NCBI Gene 3738: https://www.ncbi.nlm.nih.gov/gene/3738
- Ensembl ENSG00000177272: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000177272

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/kcna3.json