# KCND2

Source: https://onco.cc/targets/kcnd2/  
OnCo record `kcnd2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KCND2 (A-type voltage-gated potassium channel KCND2) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons. This current is activated at membrane potentials that are below the threshold for action potentials.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.74, genetic association 0.28, clinical 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: potassium voltage-gated channel subfamily D member 2; A-type voltage-gated potassium channel KCND2; Kv4.2; RK5; KIAA1044
- Tags: cancer-genes-wave
- Symbol: KCND2
- Class: other
- Biology: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons. This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity. Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5. Location: Cell membrane; Cell projection, dendrite; Synapse; Perikaryon (UniProt). Locus 7q31.31 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6238: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6238
- UniProt Q9NZV8: https://www.uniprot.org/uniprotkb/Q9NZV8/entry
- NCBI Gene 3751: https://www.ncbi.nlm.nih.gov/gene/3751
- Ensembl ENSG00000184408: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184408

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/kcnd2.json