# KCNH1

Source: https://onco.cc/targets/kcnh1/  
OnCo record `kcnh1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KCNH1 (Voltage-gated delayed rectifier potassium channel KCNH1) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarisation, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.33, clinical 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: potassium voltage-gated channel subfamily H member 1; Voltage-gated delayed rectifier potassium channel KCNH1; Kv10.1; eag; h-eag; eag1; hEAG; K(V)10.1
- Tags: cancer-genes-wave
- Symbol: KCNH1
- Class: other
- Biology: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarisation, reaches a steady-state level and do not inactivate. The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve. Channel properties are modulated by subunit assembly. Location: Cell membrane; Nucleus inner membrane; Cell projection, dendrite; Cell projection, axon (UniProt). Locus 1q32.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6250: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6250
- UniProt O95259: https://www.uniprot.org/uniprotkb/O95259/entry
- NCBI Gene 3756: https://www.ncbi.nlm.nih.gov/gene/3756
- Ensembl ENSG00000143473: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143473

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/kcnh1.json