# KCNH7

Source: https://onco.cc/targets/kcnh7/  
OnCo record `kcnh7` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KCNH7 (Voltage-gated inwardly rectifying potassium channel KCNH7) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.11, genetic association 0.27, clinical 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: potassium voltage-gated channel subfamily H member 7; Voltage-gated inwardly rectifying potassium channel KCNH7; Kv11.3; HERG3; erg3
- Tags: cancer-genes-wave
- Symbol: KCNH7
- Class: other
- Biology: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Exhibits faster activation and deactivation kinetics and slow inactivation at membrane potentials positive to 240 mV, resulting in the weakest inward rectification. Location: Cell membrane (UniProt). Locus 2q24.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18863: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18863
- UniProt Q9NS40: https://www.uniprot.org/uniprotkb/Q9NS40/entry
- NCBI Gene 90134: https://www.ncbi.nlm.nih.gov/gene/90134
- Ensembl ENSG00000184611: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184611

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/kcnh7.json