# KCNH8

Source: https://onco.cc/targets/kcnh8/  
OnCo record `kcnh8` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KCNH8 (Voltage-gated delayed rectifier potassium channel KCNH8) is a gene. The public catalogues list it as a drug target, and an approved or late-stage drug is recorded against it.

## Summary

Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.12, animal model 0.45, genetic association 0.49, clinical 0.76).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: potassium voltage-gated channel subfamily H member 8; Voltage-gated delayed rectifier potassium channel KCNH8; Kv12.1; elk3
- Tags: cancer-genes-wave
- Symbol: KCNH8
- Class: other
- Biology: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents. Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV. Shows no obvious change in the activation rate from different holding potentials. Activation is strongly dependent on the pH of the external solution. Location: Membrane (UniProt). Locus 3p24.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.76. Evidence tier "approved-drug" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18864: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18864
- UniProt Q96L42: https://www.uniprot.org/uniprotkb/Q96L42/entry
- NCBI Gene 131096: https://www.ncbi.nlm.nih.gov/gene/131096
- Ensembl ENSG00000183960: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000183960

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/kcnh8.json