# KDM3B

Source: https://onco.cc/targets/kdm3b/  
OnCo record `kdm3b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KDM3B (Lysine-specific demethylase 3B) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Medulloblastoma and Paediatric low-grade glioma.

## Summary

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumour suppressor activity.

IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Medulloblastoma, Pilocytic Astrocytoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: lysine demethylase 3B; Lysine-specific demethylase 3B; KIAA1082; NET22; C5orf7; JMJD1B
- Tags: cancer-genes-wave
- Symbol: KDM3B
- Class: tumor-suppressor
- Biology: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumour suppressor activity. Location: Nucleus (UniProt). Locus 5q31.2 (HGNC).
- Where found: Medulloblastoma: IntOGen driver in 1 cohort (MBL); Paediatric low-grade glioma: IntOGen driver in 1 cohort (PAST)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:1337: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1337
- UniProt Q7LBC6: https://www.uniprot.org/uniprotkb/Q7LBC6/entry
- NCBI Gene 51780: https://www.ncbi.nlm.nih.gov/gene/51780
- Ensembl ENSG00000120733: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000120733

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Medulloblastoma](https://onco.cc/cancers/medulloblastoma/), [Paediatric low-grade glioma](https://onco.cc/cancers/paediatric-low-grade-glioma/)

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JSON: https://onco.cc/api/v1/entities/kdm3b.json