# KDM5C

Source: https://onco.cc/targets/kdm5c/  
OnCo record `kdm5c` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KDM5C (Lysine-specific demethylase 5C) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Renal cell carcinoma, Head and neck squamous cell carcinoma, Ovarian cancer and 5 more.

## Summary

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.

CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Everolimus, Capivasertib and Sunitinib. Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.98, animal model 0.44, genetic association 0.00, somatic mutation 0.96). IntOGen calls it a driver in 10 cohorts (1 activating, 9 loss-of-function), covering Renal Clear Cell Carcinoma, Head and Neck Squamous Cell Carcinoma, Lung Adenocarcinoma, Ovarian Epithelial Tumour, Pancreatic Adenocarcinoma, Plasma Cell Myeloma and others.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: lysine demethylase 5C; Lysine-specific demethylase 5C; DXS1272E; XE169; JARID1C; MRX13
- Tags: cancer-genes-wave
- Symbol: KDM5C
- Class: transcription
- Biology: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2. Location: Nucleus (UniProt). Locus Xp11.22 (HGNC).
- Where found: Renal cell carcinoma: Open Targets association 0.68 with renal cell carcinoma (MONDO_0005086); CIViC evidence names this disease; Head and neck squamous cell carcinoma: IntOGen driver in 1 cohort (HNSC); Ovarian cancer: IntOGen driver in 1 cohort (OVT); Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD); Multiple myeloma: IntOGen driver in 1 cohort (PCM); Skin cancer: Open Targets association 0.54 with skin cancer (MONDO_0002898)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 3 therapies; IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 9 cohorts; CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11114: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11114
- UniProt P41229: https://www.uniprot.org/uniprotkb/P41229/entry
- NCBI Gene 8242: https://www.ncbi.nlm.nih.gov/gene/8242
- Ensembl ENSG00000126012: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126012

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Clear cell renal cell carcinoma](https://onco.cc/cancers/clear-cell-rcc/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/kdm5c.json