# KDM5D

Source: https://onco.cc/targets/kdm5d/  
OnCo record `kdm5d` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KDM5D (Lysine-specific demethylase 5D) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.

## Summary

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Berzosertib.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: lysine demethylase 5D; Lysine-specific demethylase 5D; KIAA0234; JARID1D
- Tags: cancer-genes-wave
- Symbol: KDM5D
- Class: transcription
- Biology: Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Location: Nucleus (UniProt). Locus Yq11.223 (HGNC).
- Where found: Prostate cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:11115: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11115
- UniProt Q9BY66: https://www.uniprot.org/uniprotkb/Q9BY66/entry
- NCBI Gene 8284: https://www.ncbi.nlm.nih.gov/gene/8284
- Ensembl ENSG00000012817: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000012817

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)

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JSON: https://onco.cc/api/v1/entities/kdm5d.json