# KIAA1549

Source: https://onco.cc/targets/kiaa1549/  
OnCo record `kiaa1549` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KIAA1549 (UPF0606 protein KIAA1549) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.

## Summary

May play a role in photoreceptor function.

Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.25, affected pathway 0.89, genetic association 0.00, somatic mutation 0.50).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: UPF0606 protein KIAA1549
- Tags: cancer-genes-wave
- Symbol: KIAA1549
- Class: other
- Biology: May play a role in photoreceptor function. Location: Membrane; Cell projection, cilium (UniProt). Locus 7q34 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:22219: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22219
- UniProt Q9HCM3: https://www.uniprot.org/uniprotkb/Q9HCM3/entry
- NCBI Gene 57670: https://www.ncbi.nlm.nih.gov/gene/57670
- Ensembl ENSG00000122778: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000122778

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- trials: [FIREFLY-1](https://onco.cc/trials/firefly-1/)

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JSON: https://onco.cc/api/v1/entities/kiaa1549.json