# KIF23

Source: https://onco.cc/targets/kif23/  
OnCo record `kif23` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KIF23 (Kinesin-like protein KIF23) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.

## Summary

Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signalling. Required for the localisation of ECT2 to the central spindle.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: kinesin family member 23; Kinesin-like protein KIF23; MKLP1; MKLP-1; KNSL5
- Tags: cancer-genes-wave
- Symbol: KIF23
- Class: other
- Biology: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signalling required for the myosin contractile ring formation during the cell cycle cytokinesis. Essential for cytokinesis in Rho-mediated signalling. Required for the localisation of ECT2 to the central spindle. Plus-end-directed motor enzyme that moves antiparallel microtubules in vitro. Location: Nucleus; Cytoplasm, cytoskeleton, spindle; Midbody, Midbody ring; Midbody (UniProt). Locus 15q23 (HGNC).
- Where found: Hepatocellular carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6392: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6392
- UniProt Q02241: https://www.uniprot.org/uniprotkb/Q02241/entry
- NCBI Gene 9493: https://www.ncbi.nlm.nih.gov/gene/9493
- Ensembl ENSG00000137807: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000137807

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

---
JSON: https://onco.cc/api/v1/entities/kif23.json