# KIVU-305

Source: https://onco.cc/drugs/kivu-305/  
OnCo record `kivu-305` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KIVU-305 is an experimental antibody-drug conjugate from Kivu Bioscience, in phase 1 trials for colorectal cancer, pancreatic cancer and gastric cancer and other cancers.

## Summary

KIVU-305 is an antibody-drug conjugate (topoisomerase inhibitor payload, DAR4) from Kivu Bioscience. A humanised, Fc-silenced CEACAM5 antibody joined by site-specific GlycoConnect conjugation to a HydraSpace-linked SYNtecan E topoisomerase inhibitor payload at a drug-to-antibody ratio of 4. Its furthest stage is phase 1, for colorectal cancer, pancreatic cancer, gastric cancer and lung cancer. ClinicalTrials.gov registers it in one study linked below. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Code: KIVU-305
- Modality: Antibody-drug conjugate (topoisomerase inhibitor payload, DAR4)
- Mechanism: A humanised, Fc-silenced CEACAM5 antibody joined by site-specific GlycoConnect conjugation to a HydraSpace-linked SYNtecan E topoisomerase inhibitor payload at a drug-to-antibody ratio of 4.

## Sources

- Kivu Bioscience: kivubioscience.com: https://kivubioscience.com/news/kivu-bioscience-presents-kivu-305-preclinical-data-at-world-adc-london-2026-and-advances-into-phase-1-clinical-trial/
- Kivu Bioscience: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT07545356
- ClinicalTrials.gov: trials of KIVU-305: https://clinicaltrials.gov/search?intr=KIVU-305

## Connected records

- cancers: [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- targets: [CEACAM5](https://onco.cc/targets/ceacam5/)
- companies: [Kivu Bioscience](https://onco.cc/companies/kivu-bioscience/)
- trials: [A Study of KIVU-305 in Participants With Locally Advanced or Metastatic Solid Tumors](https://onco.cc/trials/nct07545356/)

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JSON: https://onco.cc/api/v1/entities/kivu-305.json