# KLC1

Source: https://onco.cc/targets/klc1/  
OnCo record `klc1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KLC1 (Kinesin light chain 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.76, genetic association 0.38).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: kinesin light chain 1; Kinesin light chain 1; KNS2A; hKLC1S; hKLC1N; hKLC1P; hKLC1G; hKLC1R; hKLC1J; hKLC1B; KNS2
- Tags: cancer-genes-wave
- Symbol: KLC1
- Class: other
- Biology: Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity. Location: Cell projection, growth cone; Cytoplasmic vesicle; Cytoplasm, cytoskeleton (UniProt). Locus 14q32.33 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6387: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6387
- UniProt Q07866: https://www.uniprot.org/uniprotkb/Q07866/entry
- NCBI Gene 3831: https://www.ncbi.nlm.nih.gov/gene/3831
- Ensembl ENSG00000126214: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000126214

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/klc1.json