# KLF2

Source: https://onco.cc/targets/klf2/  
OnCo record `klf2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KLF2 (Krueppel-like factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.66).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: KLF transcription factor 2; Krueppel-like factor 2
- Tags: cancer-genes-wave
- Symbol: KLF2
- Class: transcription
- Biology: Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements. Location: Nucleus (UniProt). Locus 19p13.11 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6347: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6347
- UniProt Q9Y5W3: https://www.uniprot.org/uniprotkb/Q9Y5W3/entry
- NCBI Gene 10365: https://www.ncbi.nlm.nih.gov/gene/10365
- Ensembl ENSG00000127528: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000127528

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/klf2.json