# KLF6

Source: https://onco.cc/targets/klf6/  
OnCo record `klf6` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KLF6 (Krueppel-like factor 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Skin cancer and Melanoma.

## Summary

Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development.

Open Targets scores its association with cancer at 0.78 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.24, somatic mutation 0.93, genetic literature 0.76). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Melanoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: KLF transcription factor 6; Krueppel-like factor 6; Zf9; PAC1; BCD1; ST12; COPEB
- Tags: cancer-genes-wave
- Symbol: KLF6
- Class: tumor-suppressor
- Biology: Transcriptional activator. Binds a GC box motif. Could play a role in B-cell growth and development. Location: Nucleus (UniProt). Locus 10p15.2 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.62 with prostate cancer (MONDO_0008315); Skin cancer: Open Targets association 0.53 with skin cancer (MONDO_0002898); Melanoma: Open Targets association 0.58 with melanoma (MONDO_0005105); IntOGen driver in 1 cohort (MEL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:2235: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2235
- UniProt Q99612: https://www.uniprot.org/uniprotkb/Q99612/entry
- NCBI Gene 1316: https://www.ncbi.nlm.nih.gov/gene/1316
- Ensembl ENSG00000067082: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000067082

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Melanoma](https://onco.cc/cancers/melanoma/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/klf6.json