# KLHDC8B

Source: https://onco.cc/targets/klhdc8b/  
OnCo record `klhdc8b` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KLHDC8B (Kelch domain-containing protein 8B) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Hodgkin lymphoma.

## Summary

Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: kelch domain containing 8B; Kelch domain-containing protein 8B; MGC35097
- Tags: cancer-genes-wave
- Symbol: KLHDC8B
- Class: other
- Biology: Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis. Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells. Location: Cytoplasm; Midbody (UniProt). Locus 3p21.31 (HGNC).
- Where found: Hodgkin lymphoma: Open Targets association 0.55 with Hodgkins lymphoma (MONDO_0004952)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:28557: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28557
- UniProt Q8IXV7: https://www.uniprot.org/uniprotkb/Q8IXV7/entry
- NCBI Gene 200942: https://www.ncbi.nlm.nih.gov/gene/200942
- Ensembl ENSG00000185909: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185909

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Hodgkin lymphoma](https://onco.cc/cancers/hodgkin-lymphoma/)

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JSON: https://onco.cc/api/v1/entities/klhdc8b.json