# KLK3

Source: https://onco.cc/targets/klk3/  
OnCo record `klk3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KLK3 (Prostate-specific antigen) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.

## Summary

Hydrolyses semenogelin-1 thus leading to the liquefaction of the seminal coagulum.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 1.00, genetic association 0.74, clinical 0.61).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: kallikrein related peptidase 3; Prostate-specific antigen
- Tags: cancer-genes-wave
- Symbol: KLK3
- Class: enzyme
- Biology: Hydrolyses semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Location: Secreted (UniProt). Locus 19q13.33 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.67 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.61. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6364: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6364
- UniProt P07288: https://www.uniprot.org/uniprotkb/P07288/entry
- NCBI Gene 354: https://www.ncbi.nlm.nih.gov/gene/354
- Ensembl ENSG00000142515: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000142515

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- pathways: [Prostate cancer (KEGG map)](https://onco.cc/pathways/prostate-cancer-signalling/)

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JSON: https://onco.cc/api/v1/entities/klk3.json