# KLLN

Source: https://onco.cc/targets/klln/  
OnCo record `klln` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KLLN (Killin) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer and Renal cell carcinoma.

## Summary

DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA.

CIViC holds 2 clinical evidence items and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: killin, p53 regulated DNA replication inhibitor; Killin; killin
- Tags: cancer-genes-wave
- Symbol: KLLN
- Class: other
- Biology: DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA. Location: Nucleus (UniProt). Locus 10q23 (HGNC).
- Where found: Breast cancer: CIViC evidence names this disease; Renal cell carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:37212: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:37212
- UniProt B2CW77: https://www.uniprot.org/uniprotkb/B2CW77/entry
- NCBI Gene 100144748: https://www.ncbi.nlm.nih.gov/gene/100144748
- Ensembl ENSG00000227268: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000227268

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Renal cell carcinoma](https://onco.cc/cancers/rcc/)

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JSON: https://onco.cc/api/v1/entities/klln.json