# KSR2

Source: https://onco.cc/targets/ksr2/  
OnCo record `ksr2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

KSR2 (Kinase suppressor of Ras 2) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1.

Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.97, genetic association 0.47).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: kinase suppressor of ras 2; Kinase suppressor of Ras 2; FLJ25965
- Tags: cancer-genes-wave
- Symbol: KSR2
- Class: kinase
- Biology: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Acts as MAP2K1/MEK1-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1, dimerises with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1. Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signalling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production. Location: Cytoplasm; Membrane (UniProt). Locus 12q24.22-q24.23 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18610: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18610
- UniProt Q6VAB6: https://www.uniprot.org/uniprotkb/Q6VAB6/entry
- NCBI Gene 283455: https://www.ncbi.nlm.nih.gov/gene/283455
- Ensembl ENSG00000171435: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171435

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ksr2.json