# L3MBTL3

Source: https://onco.cc/targets/l3mbtl3/  
OnCo record `l3mbtl3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

L3MBTL3 (Lethal(3)malignant brain tumour-like protein 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.

## Summary

Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1.

Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.81, genetic association 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: L3MBTL histone methyl-lysine binding protein 3; Lethal(3)malignant brain tumor-like protein 3; KIAA1798
- Tags: cancer-genes-wave
- Symbol: L3MBTL3
- Class: transcription
- Biology: Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation. Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. Required for normal maturation of myeloid progenitor cells. Location: Nucleus (UniProt). Locus 6q23.1 (HGNC).
- Where found: Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:23035: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:23035
- UniProt Q96JM7: https://www.uniprot.org/uniprotkb/Q96JM7/entry
- NCBI Gene 84456: https://www.ncbi.nlm.nih.gov/gene/84456
- Ensembl ENSG00000198945: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000198945

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/l3mbtl3.json