# LAMA5

Source: https://onco.cc/targets/lama5/  
OnCo record `lama5` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LAMA5 (Laminin subunit alpha-5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signalling and PTK2B/PYK2.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.89, animal model 0.44, genetic association 0.64, somatic mutation 0.23).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: laminin subunit alpha 5; Laminin subunit alpha-5
- Tags: cancer-genes-wave
- Symbol: LAMA5
- Class: other
- Biology: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. Plays a role in the regulation of skeletogenesis, through a mechanism that involves integrin-mediated signalling and PTK2B/PYK2. Location: Secreted, extracellular space, extracellular matrix, basement membrane (UniProt). Locus 20q13.33 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6485: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6485
- UniProt O15230: https://www.uniprot.org/uniprotkb/O15230/entry
- NCBI Gene 3911: https://www.ncbi.nlm.nih.gov/gene/3911
- Ensembl ENSG00000130702: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000130702

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/lama5.json