# LAMC1

Source: https://onco.cc/targets/lamc1/  
OnCo record `lamc1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LAMC1 (Laminin subunit gamma-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.96, animal model 0.44, genetic association 0.70).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: laminin subunit gamma 1; Laminin subunit gamma-1; LAMB2
- Tags: cancer-genes-wave
- Symbol: LAMC1
- Class: other
- Biology: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway. Location: Secreted, extracellular space, extracellular matrix, basement membrane (UniProt). Locus 1q25.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6492: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6492
- UniProt P11047: https://www.uniprot.org/uniprotkb/P11047/entry
- NCBI Gene 3915: https://www.ncbi.nlm.nih.gov/gene/3915
- Ensembl ENSG00000135862: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000135862

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/lamc1.json