# LATS1

Source: https://onco.cc/targets/lats1/  
OnCo record `lats1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LATS1 (Serine/threonine-protein kinase LATS1) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Cervical cancer, Breast cancer, Ovarian cancer and 4 more.

## Summary

Negative regulator of YAP1 in the Hippo signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.

Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes literature 0.99, animal model 0.41, genetic association 0.00, somatic mutation 0.87). IntOGen calls it a driver in 6 cohorts (1 activating, 5 loss-of-function), covering Basal Cell Carcinoma, Invasive Breast Carcinoma, Cervical Adenocarcinoma, Cervical Squamous Cell Carcinoma, Ovarian Epithelial Tumour, Pancreatic Adenocarcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: large tumor suppressor kinase 1; Serine/threonine-protein kinase LATS1; WARTS
- Tags: cancer-genes-wave
- Symbol: LATS1
- Class: kinase
- Biology: Negative regulator of YAP1 in the Hippo signalling pathway that plays a pivotal role in organ size control and tumour suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumour suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, spindle; Midbody; Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body (UniProt). Locus 6q25.1 (HGNC).
- Where found: Cervical cancer: IntOGen driver in 2 cohorts (CEAD, CESC); Breast cancer: IntOGen driver in 1 cohort (BRCA); Ovarian cancer: IntOGen driver in 1 cohort (OVT); Pancreatic ductal adenocarcinoma: IntOGen driver in 1 cohort (PAAD); Skin cancer: Open Targets association 0.55 with skin cancer (MONDO_0002898); Colorectal cancer: Open Targets association 0.53 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort; IntOGen calls it a loss-of-function (LoF) driver in 5 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6514: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6514
- UniProt O95835: https://www.uniprot.org/uniprotkb/O95835/entry
- NCBI Gene 9113: https://www.ncbi.nlm.nih.gov/gene/9113
- Ensembl ENSG00000131023: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000131023

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Basal cell carcinoma](https://onco.cc/cancers/basal-cell-carcinoma/), [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Cervical cancer](https://onco.cc/cancers/cervical/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)
- pathways: [Hippo-YAP/TAZ](https://onco.cc/pathways/hippo-yap/)

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JSON: https://onco.cc/api/v1/entities/lats1.json