# LMO1

Source: https://onco.cc/targets/lmo1/  
OnCo record `lmo1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

LMO1 (Rhombotin-1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors.

Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes literature 0.95, genetic association 0.37, somatic mutation 0.96).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: LIM domain only 1; Rhombotin-1; TTG1; RHOM1; RBTN1
- Tags: cancer-genes-wave
- Symbol: LMO1
- Class: other
- Biology: May be involved in gene regulation within neural lineage cells potentially by direct DNA binding or by binding to other transcription factors. Location: Nucleus (UniProt). Locus 11p15.4 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.51 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:6641: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6641
- UniProt P25800: https://www.uniprot.org/uniprotkb/P25800/entry
- NCBI Gene 4004: https://www.ncbi.nlm.nih.gov/gene/4004
- Ensembl ENSG00000166407: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000166407

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/lmo1.json